舒芬太尼和异丙酚：全凭静脉麻醉

本文由“小麻哥的日常"授权转载

摘要译文（供参考）

舒芬太尼和异丙酚复🈴全凭静脉麻醉在乳腺癌根治术中的临床价值

目的：

探讨舒芬太尼复合异丙酚用于全凭静脉麻醉（TIVA）乳腺癌根治术的临床价值。

方法：

回顾性分析我院2020年2月至2021 2月120例乳腺癌根治术患者的资料，将其随机分为实验组（EXG）（n=60）和对照组（COG）（n=60）（这里不是特别明白，回顾性分析怎么能随机分组？有大神知道的不吝赐教，万分感谢！）。

麻醉维持方案：

实验组：舒芬太尼0.01-0.03 μg/(kg·min) 和异丙酚80-100 μg/(kg·min) ；

对照组：芬太尼3 μg/(kg·h) + 异丙酚80-100 μg/(kg·min)。

比较EXG和COG两组的血流动力学指数、应激指数、术后疼痛评分和不良反应发生率。

结果：

EXG组气管插管后（T2）、深部组织分离时（T3）、拔管时（T4）和手术结束时（T5）的心率（HR）和平均动脉压（MAP）明显低于COG组（P<0.001）。

EXG组在术后1小时（T6）、6小时（T7）和12小时（T8）的应激指数和术后疼痛评分低于COG组（P<0.001）。

EXG组头晕、头痛、瘙痒和出现躁动的发生率低于COG组（P<0.05）。

结论：

舒芬太尼和异丙酚复🈴TIVA可稳定乳腺癌根治术患者术中血流动力学指标，减轻围手术期应激反应，减少疼痛感。

因此，这种麻醉方法是安全的，值得临床推广。

原文摘要

Clinical Value of Total Intravenous Anesthesia with Sufentanil and Propofol in Radical Mastectomy

Objective: 

To investigate the clinical value of sufentanil combined with propofol for total intravenous anesthesia (TIVA) in radical mastectomy.

Methods: 

The data of 120 patients undergoing radical mastectomy of breast cancer in our hospital from February 2020 to February 2021 were retrospectively analyzed, and they were randomly assigned to the experimental group (EXG) (n = 60) and the control group (COG) (n = 60). 

The anesthesia maintenance scheme was 0.01-0.03 μg/(kg·min) of sufentanil + 80-100 μg/(kg·min) of propofol in EXG and 3 μg/(kg·h) of fentanyl + 80-100 μg/(kg·min) of propofol in COG. 

The hemodynamic indices, stress indexes, postoperative pain scores, and incidence of adverse reactions were compared between EXG and COG.

Results: 

The heart rates (HR) and mean arterial pressure (MAP) after tracheal intubation (T2) and at separation of deep tissues (T3), tracheal extubation (T4), and the end of surgery (T5) were markedly lower in EXG than in COG (P < 0.001). 

The stress indexes and postoperative pain scores at 1 h (T6), 6 h (T7), and 12 h (T8) after surgery were lower in EXG than in COG (P < 0.001). 

The incidence of dizziness, headache, pruritus, and emergence agitation in EXG was lower compared with that in COG (P < 0.05).

Conclusion: 

Sufentanil combined with propofol for TIVA can stabilize intraoperative hemodynamic indices of patients undergoing radical mastectomy, alleviate perioperative stress response, and reduce pain perception. 

Therefore, this anesthesia method is safe and merits clinical promotion.