上海交通大学医学院附属上海儿童医学中心麻醉科郑吉建主任团队——追光·中国麻醉行业科研一览（2021-2022）-华东篇

前言

PREFACE

岁月荏苒，时光不居，创新中国笃行致远，搭建起广阔的平台，赋予麻醉学更多的历史机遇。近年来，国内麻醉学日新月异，科研成果层出不穷，在国内外权威期刊上重磅发表，攀画学科发展的崭新蓝图，为行业崛起注入了源源动力。

见微知著，原始见终，为集中展示中国麻醉行业科研新成果，促进麻醉行业不同领域间学习交流，激励麻醉同仁攻坚克难、勇毅前行，积极投身学科科研事业，特精选一批颜具代表性的研究成果，汇编成册，以飨共勉。

借此契机，我们也将优秀企业的科研成果、发展规划，及企业管理者的科研感悟集萃汇编，展示中国企业麻醉、围术期产品科研创新成就，供行业内互动分享，推动行业再攀新高峰，再创新辉煌。

湖平两岸阔，风正一帆悬。让我们携手共进、志存高远，共同见证中国麻醉行业科研创新的累累硕果，共同见证榜样的澎湃力量!

上海交通大学医学院

附属上海儿童医学中心麻醉科

郑吉建主任

◆医学博士，主任医师，博士研究生导师

◆上海交通大学医学院附属上海儿童医学中心麻醉科主任，麻醉与危重医学教研室主任

◆现任中国心胸血管麻醉学会非心脏手术麻醉分会和小儿麻醉分会常委兼秘书长

◆中国医药教育协会临床用药评价专业委员会理事兼儿童用药评价分会委员

◆上海市麻醉专科委员会小儿学组副组长

◆上海中西医结合麻醉与镇痛学会常委

◆《中华麻醉学杂志》、《中国毕业后医学教育》编委等

◆长期从事麻醉与危重医学临床、教学与科研工作，积累了丰富的经验。在国家自然基金资助下，长期从事神经发育电生理及药理学研究，尤其是研究发育过程中的神经保护。作为第一作者或通讯作者在Nature Neuroscience、Neuron、Anesthesia & Analgesia等杂志发表SCI论文30余篇。部分工作受到Science STKE、Nature Neuroscience、Trends in Neuroscience 和 Faculty1000 等杂志的高度评价

（科室风采）

上海儿童医学中心麻醉科近2年获得上海市2020年度“科技创新行动计划” 自然科学基金项目2项，上海市2020年度“科技创新行动计划” 科普专项基金1项，上海市卫健委项目1项，上海浦东新区科委项目1项。发表相关SCI论文22篇。

课题

1. 张马忠，LncRNA Silc1调节Elavl4/GAP43诱发青春期迟发神经病理性疼痛机制的研究（项目编号20ZR1434600 ），上海市2020年度“科技创新行动计划” 自然科学基金项目（2020.7.1-2023.6.30），20万

2. 侯慧艳，使用高还原度场景插图宣传小册子和卡通动画视频进行麻醉术前科普宣教对小儿术前焦虑的影响（20DZ2306700），上海市2020年度“科技创新行动计划” 科普专项基金（2020.9.1-2021.8.31），20万

3. 郑吉建，circRanbp9-microRNAs-RanBP9表达上调参与介导全身麻醉药神经发育毒性的易感窗口期研究（21ZR1441100），上海市科委自然科学基金（2021.7-2024.06）， 20万

4. 孙瑛，体位性肺复张对侧进胸体外循环行先心纠治术患儿术后肺不张影响的随机对照临床研究（PKJ2020-Y07），浦东新区科技发展基金民生科研专项资金医疗卫生项目（2020.9.1-2023.8.30），12万

5. 许文妍，建立基于代谢基因多态性的罗库溴铵作用时效预测模型并优化小儿短时手术肌松管理策略的研究（202140435），上海市卫生健康委员会（2022.01-2024.12），10万

发表SCI论文22篇

1. Hualin Chen, Kan Zhang, Hongbin Gu, Bai Jie, Jijian Zheng, Mazhong Zhang. A new technique to facilitate lung lavage for pulmonary alveolar proteinosis in a 3-month-old infant: Bronchial-blocker-out-of-endotracheal-tube technique. J Clin Anesth. 2020 Feb;59:82-83. doi: 10.1016/j.jclinane. 2019.06.018. Epub 2019 Jul 3.

2. Lei Wu, Qiaoru Hou, Jie Bai, Jianwei Zhang, Liping Sun, Ruizhen Tan, Mazhong Zhang, Jijian Zheng . Modified Lung Ultrasound Examinations in Assessment and Monitoring of Positive End-Expiratory Pressure-Induced Lung Reaeration in Young Children With Congenital Heart Disease Under General Anesthesia. Pediatr Crit Care Med. 2019 May; 20(5):442-449. doi: 10.1097/PCC. 0000000000001865.

3. Wenyan Xu, Yue Huang, Jie Bai, Anna M Varughese. A quality improvement project to reduce postoperative adverse respiratory events and increase safety in the postanesthesia care unit of a pediatric institution. Paediatr Anaesth. 2019 Feb; 29(2):200-210. doi: 10.1111/pan.13534.

4. Sen Zhang, Ruidong Zhang, Meihua Cai, Kan Zhang, Mazhong Zhang, Jijian Zheng. Intranasal dexmedetomidine premedication in children with recent upper respiratory tract infection undergoing interventional cardiac catheterisation: A randomised controlled trial. Eur J Anaesthesiol. 2020 Feb;37(2):85-90. doi: 10.1097/EJA.0000000000001097.

5. Sen Zhang, Ruidong Zhang, Meihua Cai, Kan Zhang, Mazhong Zhang, Jijian Zheng. A new technique to facilitate lung lavage for pulmonary alveolar proteinosis in a 3-month-old infant: Bronchial-blocker-out-of-endotracheal-tube technique. Eur J Anaesthesiol. 2020 Feb;37(2):85-90. doi: 10.1097/EJA.0000000000001097.

6. Bo Li, Ruidong Zhang, Yue Huang, Kan Zhang, Chun Yin Wat, Jie Bai, Mazhong Zhang, Jijian Zheng. Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children's hospitals in China: a questionnaire survey from China. BMC Health Serv Res . 2020 Jan 8;20(1):28. doi: 10.1186/s12913-019-4885-4.

7. Lei Wu, Kan Zhang, Liping Sun, Jie Bai, Mazhong Zhang, Jijian Zheng. Laminin degradation by matrix metalloproteinase 9 promotes ketamine-induced neuronal apoptosis in the early developing rat retina. CNS Neurosci Ther. 2020;26(10):1058-1068. doi: 10.1111/cns.13428. Epub 2020 Jun 20.

8. Liping Sun, Lei Wu, Kan Zhang, Ruizhen Tan, Jie Bai, Mazhong Zhang, Jijian Zheng. Lung ultrasound evaluation of incremental PEEP recruitment maneuver in children undergoing cardiac surgery.  Pediatr Pulmonol. Pediatr Pulmonol. 2020 May;55(5):1273-1281. doi: 10.1002/ppul.24720. Epub 2020 Mar 9.

9. Kan Zhang, Siyuan Wang, Mengqi Li, Chi Wu, Liping Sun, Sen Zhang, Jie Bai, Mazhong Zhang, Jijian Zheng. Anesthesia timing for children undergoing therapeutic cardiac catheterization after upper respiratory infection: a prospective observational study. Minerva Anestesiol . 2020 Aug;86(8):835-843. doi: 10.23736/S0375-9393.20.14293-7. Epub 2020 Apr 6.

10. Yun'an Song, Huiyan Hou, Jie Bai, Hongbin Gu. Prediction of Fluid Responsiveness by Stroke Volume Variation in Children Undergoing Fontan Operation. Biomed Res Int. 2020 Nov 7; 2020: 2595960. doi: 10.1155/2020/2595960. eCollection 2020.

11. Yan-Yan Yang, Ma-Zhong Zhang, Ying Sun, Zhe-Zhe Peng, Pei-Pei Liu, Yan-Ting Wang, Ji-Jian Zheng, Jun-Zheng Wu. Effect of recorded maternal voice on emergence agitation in children undergoing bilateral ophthalmic surgery: A randomised controlled trial. J Paediatr Child Health. 2020 Sep;56(9):1402-1407. doi: 10.1111/jpc.14948. Epub 2020 Jun 30.

12. Kan Zhang, Lei Wu, Kana Lin, Mazhong Zhang, Weiguang Li, Xiaoping Tong, Jijian Zheng. Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development. Exp Neurol. 2021 Jun;340:113659. doi: 10.1016/j.expneurol.2021.113659. Epub 2021 Feb 26.

13. Chi Wu, Jie Bai. Mucinous histology as a poor prognostic factor in young patients with Stage II rectal cancer: A population-based study. J Cancer Res Ther. 2020;16(7):1664-1671. doi: 10.4103/jcrt. JCRT_567_20.

14. Yong Bian, Yanhui Huang, Jie Bai, Jijian Zheng, Yue Huang. A randomized controlled trial of ultrasound-assisted techniaue versus conventional puncture method for saphenous venous cannulations in children with congenital heart diseas. BMC Anesthesiol. 2021 Apr 27;21(1):131. doi: 10.1186/s12871-021-01349-y.

15. Gu H, Song Y, Bai J. ED50 of Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography in Children with or without a History of Cardiac Surgery for Cyanotic Congenital Heart Disease. Biomed Res Int. 2020 Dec 12; 2020: 1349432. doi: 10.1155/2020/1349432. eCollection 2020.

16. Yang Shen, Yan-Ting Wang, Zhe-Zhe Peng, Jie Bai, Ji-Jian Zheng, Ma-Zhong Zhang, Ying Sun. Comparison of the ED50 propofol requirements during the insertion of laryngeal mask airway Ambu AuraFlex with Ambu AuraOnce in children undergoing strabismus surgery. J Clin Pharm Ther. 2021 Dec;46(6):1629-1635. doi: 10.1111/jcpt.13506. Epub 2021 Aug 2.

17. Pan He, Chi Wu, Yanyan Yang, Jijian Zheng, Wei Dong, Junzheng Wu, Ying Sun, Mazhong Zhang. Effectiveness of postural lung recruitment on postoperative atelectasis assessed by lung ultrasound in children undergoing lateral thoracotomy cardiac surgery with cardiopulmonary bypass. Pediatr Pulmonol. 2021 Jun;56(6):1724-1732. doi: 10.1002/ppul.25315. Epub 2021 Feb 23.

18. Zhe Zhe Peng,Yan Ting Wang,Ma Zhong Zhang,Ji Jian Zheng,Jie Hu,Wan Ru Zhou,Ying Sun . Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants undergoing cleft palate repair: a randomized controlled trial. BMC Pediatr . 2021 Oct 22;21(1):466. doi: 10.1186/s12887-021-02907-6.

19. Bo Li, Huiyan Hou, Jie Bai, Mazhong Zhang, Shengde Li, Jijian Zheng. Paediatric preoperative sedationpractices in tertiary maternity and children's hospitals in China: a questionnaire survey. BMC Pediatr. 2021 Aug 9; 21(1):336. doi: 10.1186/s12887-021-02802-0.

20. Liping Sun, Kan Zhang, Hualin Chen, Wei Ji, Yue Huang, Mazhong Zhang, Jijian Zheng. Age-Related Changes in Cerebral Hemodynamics in Children Undergoing Congenital Cardiac Surgery: A Prospective Observational Study.  J Cardiothorac Vasc Anesth. 2022 Jun;36(6):1617-1624. doi: 10.1053/j.jvca.2021.08.099. Epub 2021 Sep 4.

21. Ruidong Zhang,Jie Hu,Shengde Li,Bin Xue,Lu Wang,Jie Bai,Jijian Zheng. Effects of age on sugammadex reversal of neuromuscular blockade induced by rocuronium in Chinese children: a prospective pilot trial. BMC Anesthesiol. 2021 Oct 19; 21(1):248. doi: 10.1186/s12871-021-01465-9.

22. Bian Y, Zhou S, Hou H, Xu T, Huang Y. The optimal dose of oral midazolam with or without intranasal S-ketamine for premedication in children: a randomised, double blinded, sequential dose-finding trial. Transl Pediatr. 2021 Nov; 10(11):2941-2951. doi: 10.21037/tp-21-247.

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